KMT2A

gene product
ALL-1, CXXC7, HRX, HTRX1, MLL, MLL1A, TRX1
This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010]
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452 antibodies from 33 providers.

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Novus Biologicals
49 antibodies
antibodies-online
149 antibodies
GeneTex
3 antibodies
Invitrogen Antibodies
3 antibodies
Bethyl Laboratories
5 antibodies
OriGene
3 antibodies
Biorbyt
13 antibodies
Acris Antibodies GmbH
5 antibodies
LifeSpan BioSciences, Inc.
102 antibodies
Abnova Corporation
4 antibodies
Cell Signaling Technology, Inc
2 antibodies
Affinity Biosciences
1 antibody
Abgent
4 antibodies
Arigo
2 antibodies
ProSci
4 antibodies
St John's Laboratory
4 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Creative Biolabs
17 antibodies
RabMAbs
1 antibody
Atlas Antibodies
1 antibody
Aviva Systems Biology
1 antibody
EMD Millipore
3 antibodies
MyBioSource
4 antibodies
RayBiotech, Inc.
3 antibodies
Creative Diagnostics
2 antibodies
Abiocode, Inc.
1 antibody
Active Motif
1 antibody
Boster Biological Technology
1 antibody
GenWay
1 antibody
United States Biological
54 antibodies
Sigma-Aldrich
4 antibodies
Leading Biology
3 antibodies
Abbiotec
1 antibody