ZEB2

The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2010]

Description

zinc finger E-box binding homeobox 2

Protein family

Disease related genes, Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Predicted intracellular proteins, Protein evidence (Peptideatlas), Transcription factors

Chromosome

2:q22.3 (144364364 - 144521057)

Ensembl ID

ENSG00000169554  (ver. 99.38)

Orthologs

Mouse Zeb2: ENSMUSG00000026872

UniProt

O60315

neXtProt

NX_O60315

Human splice variants
Mouse splice variants