Explore
Validate
LearnTissue expression
Cell line expression
Protein structure
PLAU
Plasminogen activator, urokinaseUPA, URK
This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Top validated antibodies |
|||||
| Proteintech Group |  17968-1-AP |
40 references | Polyclonal |
WB
EL
ICC
IP
IHC
|
|
| Invitrogen Antibodies | 17968-1-AP |
Polyclonal |
WB
ICC
IP
IHC
OA
|
||
| LSBio | LS-C100932 |
Polyclonal |
WB
ICC
IHC
|
||
| Abcepta | AP8161a |
3 references | Polyclonal |
WB
IHC
FC
|
|
| Novus Biologicals | AF1310 |
4 references | Polyclonal |
WB
IP
IHC
|
|
All Antibodies
Filters
Enhanced validation Supportive data in Antibodypedia Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider