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Protein structure
PLAU
Plasminogen activator, urokinaseUPA, URK
This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Top validated antibodies |
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| Proteintech Group |  17968-1-AP |
22 references | Polyclonal |
WB
EL
ICC
IP
IHC
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| Invitrogen Antibodies | 17968-1-AP |
Polyclonal |
WB
ICC
IP
IHC
OA
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| Abgent | AP8161a |
3 references | Polyclonal |
WB
IHC
FC
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| Novus Biologicals | AF1310 |
4 references | Polyclonal |
WB
IP
IHC
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| R&D Systems | AF1310 |
4 references | Polyclonal |
WB
IP
IHC
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