Tissue expression
Cell line expression
Protein structure

GCK

Glucokinase
HK4, MODY2 
This gene encodes a member of the hexokinase family of proteins. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. The use of multiple promoters and alternative splicing of this gene result in distinct protein isoforms that exhibit tissue-specific expression in the pancreas and liver. In the pancreas, this enzyme plays a role in glucose-stimulated insulin secretion, while in the liver, this enzyme is important in glucose uptake and conversion to glycogen. Mutations in this gene that alter enzyme activity have been associated with multiple types of diabetes and hyperinsulinemic hypoglycemia. [provided by RefSeq, Aug 2017]
More gene data

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618 antibodies from 35 providers.

Antibody properties

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AntibodyRefsTypeWBELICCIPIHCFC
Proteintech Group
5 antibodies
Invitrogen Antibodies
26 antibodies
GeneTex
6 antibodies
Bioss
1 antibody
antibodies-online
164 antibodies
Abnova Corporation
11 antibodies
Biorbyt
99 antibodies
OriGene
18 antibodies
NovoPro Bioscience Inc.
4 antibodies
Abgent
5 antibodies
NSJ Bioreagents
2 antibodies
Novus Biologicals
34 antibodies
Cusabio Biotech Co., Ltd
8 antibodies
Acris Antibodies GmbH
7 antibodies
Boster Biological Technology
3 antibodies
FineTest Biotech
2 antibodies
Bioworld Technology, Inc
2 antibodies
Atlas Antibodies
2 antibodies
Affinity Biosciences
1 antibody
ProSci
1 antibody
St John's Laboratory
6 antibodies
RabMAbs
4 antibodies
MyBioSource
8 antibodies
Arigo
2 antibodies
RayBiotech, Inc.
2 antibodies
Aviva Systems Biology
3 antibodies
Leading Biology
4 antibodies
Creative Diagnostics
6 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
R&D Systems
1 antibody
Abbexa
13 antibodies
Creative Biolabs
13 antibodies
United States Biological
52 antibodies
MilliporeSigma / Merck KGaA
4 antibodies