MAP4K4

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Description

Mitogen-activated protein kinase kinase kinase kinase 4

Tissue specificity

Tissue enhanced (brain)

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

2:q11.2 (101696850 - 101894689)

Ensembl ID

ENSG00000071054  (ver. 103.38)

Orthologs

Mouse Map4k4: ENSMUSG00000026074

UniProt

O95819

neXtProt

NX_O95819

Human splice variants
Mouse splice variants