Tissue expression
Cell line expression
Protein structure
EGLN1
Egl-9 family hypoxia inducible factor 1C1orf12, HIFPH2, PHD2, SM-20, ZMYND6
The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3). [provided by RefSeq, Nov 2009]
Top validated antibodies |
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Novus Biologicals | NB100-138 | 14 references | Polyclonal |
WB
ICC
IP
IHC
FC
IEM |
|
antibodies-online | ABIN151071 | 66 references | Polyclonal |
WB
ICC
IP
IHC
FC
|
|
GeneTex | GTX10930 | Polyclonal |
WB
ICC
IP
IHC
FC
IEM |
||
Abnova Corporation | PAB14555 | 3 references | Polyclonal |
WB
IHC
FC
|
|
Proteintech Group | 19886-1-AP | 4 references | Polyclonal |
WB
EL
IHC
|
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Supportive data in Antibodypedia
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Recommended by provider