Tissue expression
Cell line expression

FBXW7

gene product
AGO, CDC4, FBW7, FBX30, FBXW6, FLJ11071, SEL-10, SEL10 
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
More gene data

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653 antibodies from 36 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Invitrogen Antibodies
8 antibodies
Novus Biologicals
63 antibodies
antibodies-online
150 antibodies
Abnova Corporation
8 antibodies
Proteintech Group
2 antibodies
OriGene
102 antibodies
HUABIO Research
1 antibody
LifeSpan BioSciences, Inc.
110 antibodies
Acris Antibodies GmbH
9 antibodies
NovoPro Bioscience Inc.
3 antibodies
Abgent
3 antibodies
Wuhan Fine Biotech Co., Ltd.
1 antibody
Aviva Systems Biology
2 antibodies
Biorbyt
28 antibodies
R&D Systems
1 antibody
Cusabio Biotech Co., Ltd
6 antibodies
Bethyl Laboratories
3 antibodies
GeneTex
2 antibodies
St John's Laboratory
2 antibodies
Affinity Biosciences
1 antibody
Arigo
2 antibodies
Creative Diagnostics
8 antibodies
MyBioSource
8 antibodies
NSJ Bioreagents
2 antibodies
MilliporeSigma / Merck KGaA
4 antibodies
Creative Biolabs
26 antibodies
RayBiotech, Inc.
3 antibodies
Abiocode, Inc.
2 antibodies
United States Biological
60 antibodies
Abbexa
9 antibodies
Leading Biology
3 antibodies
ProSci
2 antibodies
EMD Millipore
1 antibody
RabMAbs
1 antibody
Exalpha Biologicals, Inc.
2 antibodies