GRM5

This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. A pseudogene of this gene has been defined on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Description

Glutamate metabotropic receptor 5

Tissue specificity

Tissue enriched (brain)

Predicted location

Intracellular, Membrane

Protein family

FDA approved drug targets
G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Kim et al 2014)
Transporters

Chromosome

11 (88504576 - 89065945)

Ensembl ID

ENSG00000168959  (ver. 103.38)

Orthologs

Mouse Grm5: ENSMUSG00000049583

UniProt

P41594

neXtProt

NX_P41594

Human splice variants
Mouse splice variants

Protein structure