PPP1R12A

gene product
M130, MBS, MYPT1
Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]
More gene data

Featured antibodies

Antibodies

 

Filters

Antibodypedia Validation Initiative

Validation method

Application

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

  or   Clear
Validated by best practice
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Validated within AVI
Eligible for validation within AVI
404 antibodies from 31 providers.

Antibody properties

Applications

or Cancel
AntibodyRefsTypeAVIWBELICCIPIHCFC
NovoPro Bioscience Inc.
2 antibodies
Biorbyt
23 antibodies
Cell Signaling Technology, Inc
6 antibodies
LifeSpan BioSciences, Inc.
60 antibodies
Aviva Systems Biology
3 antibodies
Acris Antibodies GmbH
6 antibodies
Proteintech Group
1 antibody
Invitrogen Antibodies
8 antibodies
OriGene
8 antibodies
Abnova Corporation
3 antibodies
NSJ Bioreagents
2 antibodies
antibodies-online
121 antibodies
Bioworld Technology, Inc
3 antibodies
Novus Biologicals
6 antibodies
Bethyl Laboratories
2 antibodies
RabMAbs
4 antibodies
Abbkine
4 antibodies
GeneTex
3 antibodies
Creative Diagnostics
11 antibodies
Boster Biological Technology
2 antibodies
Atlas Antibodies
1 antibody
St John's Laboratory
4 antibodies
MyBioSource
7 antibodies
Abgent
3 antibodies
EMD Millipore
7 antibodies
United States Biological
39 antibodies
Arigo
1 antibody
BioLegend (formerly Covance Antibody Products)
1 antibody
RayBiotech, Inc.
1 antibody
Sigma-Aldrich
2 antibodies