KCNJ5

This gene encodes an integral membrane protein which belongs to one of seven subfamilies of inward-rectifier potassium channel proteins called potassium channel subfamily J. The encoded protein is a subunit of the potassium channel which is homotetrameric. It is controlled by G-proteins and has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Naturally occurring mutations in this gene are associated with aldosterone-producing adenomas. [provided by RefSeq, Aug 2017]

Description

Potassium inwardly rectifying channel subfamily J member 5

Tissue specificity

Tissue enhanced (adrenal gland, pancreas)

Predicted location

Membrane

Protein family

Cancer-related genes
Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Potential drug targets
Predicted membrane proteins
Protein evidence (Kim et al 2014)
Transporters
Voltage-gated ion channels

Chromosome

11:q24.3 (128891356 - 128921163)

Ensembl ID

ENSG00000120457  (ver. 103.38)

Orthologs

Mouse Kcnj5: ENSMUSG00000032034

UniProt

P48544

neXtProt

NX_P48544

Human splice variants
Mouse splice variants