AXL

The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

Description

AXL receptor tyrosine kinase

Tissue specificity

Low tissue specificity

Subcell location

Vesicles, Plasma membrane, Actin filaments

Predicted location

Membrane

Protein family

Disease related genes
Enzymes
FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Plasma proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

19 (41219223 - 41261766)

Ensembl ID

ENSG00000167601  (ver. 103.38)

Orthologs

Mouse Axl: ENSMUSG00000002602

UniProt

P30530

neXtProt

NX_P30530

Human splice variants
Mouse splice variants

Protein structure