Tissue expression
Cell line expression

BTRC

gene product
beta-TrCP1, betaTrCP, bTrCP, bTrCP1, FBXW1A, Fwd1 
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6. [provided by RefSeq, Mar 2012]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Antigen sequence

Conjugate

Epitope

Antibody

  or   Clear
Enhanced validation
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
380 antibodies from 31 providers.

Antibody properties

Applications

or Cancel
AntibodyRefsTypeWBELICCIPIHCFC
antibodies-online
92 antibodies
Invitrogen Antibodies
22 antibodies
Novus Biologicals
58 antibodies
LifeSpan BioSciences, Inc.
60 antibodies
Acris Antibodies GmbH
3 antibodies
Biorbyt
10 antibodies
OriGene
29 antibodies
NSJ Bioreagents
2 antibodies
GeneTex
2 antibodies
NovoPro Bioscience Inc.
3 antibodies
Aviva Systems Biology
3 antibodies
Abgent
3 antibodies
Cusabio Biotech Co., Ltd
4 antibodies
Affinity Biosciences
1 antibody
Abnova Corporation
2 antibodies
R&D Systems
1 antibody
Bioworld Technology, Inc
1 antibody
ProSci
1 antibody
Cell Signaling Technology, Inc
2 antibodies
Boster Biological Technology
1 antibody
Creative Biolabs
16 antibodies
Everest Biotech
1 antibody
MyBioSource
7 antibodies
Atlas Antibodies
1 antibody
United States Biological
37 antibodies
Abbexa
7 antibodies
Leading Biology
3 antibodies
Proteintech Group
1 antibody
RabMAbs
1 antibody
Creative Diagnostics
5 antibodies
MilliporeSigma / Merck KGaA
1 antibody