FASTK

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined. [provided by RefSeq, Jul 2008]

Description

Fas activated serine/threonine kinase

Tissue specificity

Low tissue specificity

Subcell location

Nuclear speckles, Mitochondria

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

7 (151076593 - 151080866)

Ensembl ID

ENSG00000164896  (ver. 103.38)

Orthologs

Mouse Fastk: ENSMUSG00000028959

UniProt

Q14296

neXtProt

NX_Q14296

Human splice variants
Mouse splice variants

Protein structure