RBFOX2

This gene is one of several human genes similar to the C. elegans gene Fox-1. This gene encodes an RNA binding protein that is thought to be a key regulator of alternative exon splicing in the nervous system and other cell types. The protein binds to a conserved UGCAUG element found downstream of many alternatively spliced exons and promotes inclusion of the alternative exon in mature transcripts. The protein also interacts with the estrogen receptor 1 transcription factor and regulates estrogen receptor 1 transcriptional activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Description

RNA binding protein, fox-1 homolog (C. elegans) 2

Protein family

Mapped to UniProt SWISS-PROT, Predicted intracellular proteins, Protein evidence (Ezkurdia et al 2014), Protein evidence (Kim et al 2014)

Chromosome

22:q12.3 (35738736 - 36028425)

Ensembl ID

ENSG00000100320  (ver. 84.38)

Orthologs

Mouse Rbfox2: ENSMUSG00000033565

UniProt

O43251

neXtProt

NX_O43251

Human splice variants
Mouse splice variants