LEP

gene product
OB, OBS
This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq, Jul 2008]
More gene data

Antibodies

 

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Antibodypedia Validation Initiative

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Reactivity

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Conjugate

  or   Clear
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Validated within AVI
Eligible for validation within AVI
1286 antibodies from 39 providers.

Antibody properties

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Applications

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AntibodyRefsTypeWBELICCIPIHCFC
R&D Systems
7 antibodies
antibodies-online
425 antibodies
Invitrogen Antibodies
16 antibodies
Biorbyt
88 antibodies
Acris Antibodies GmbH
31 antibodies
OriGene
31 antibodies
NSJ Bioreagents
6 antibodies
Abgent
7 antibodies
Novus Biologicals
105 antibodies
GeneTex
26 antibodies
LifeSpan BioSciences, Inc.
280 antibodies