CD86

This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, May 2011]

Description

CD86 molecule

Tissue specificity

Tissue enhanced (lymphoid tissue)

Subcell location

Plasma membrane, Centriolar satellite

Predicted location

Intracellular, Membrane

Protein family

CD markers
FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

3 (122055362 - 122121139)

Ensembl ID

ENSG00000114013  (ver. 103.38)

Orthologs

Mouse Cd86: ENSMUSG00000022901

UniProt

P42081

neXtProt

NX_P42081

Human splice variants
Mouse splice variants

Protein structure