RIPK1

This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein plays a role in inflammation and cell death in response to tissue damage, pathogen recognition, and as part of developmental regulation. RIPK1/RIPK3 kinase-mediated necrosis is referred to as necroptosis. Genetic disruption of this gene in mice results in death shortly after birth. [provided by RefSeq, Aug 2017]

Description

receptor interacting serine/threonine kinase 1

Protein family

Enzymes, Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Predicted intracellular proteins, Protein evidence (Peptideatlas)

Chromosome

6:p25.2 (3063991 - 3115187)

Ensembl ID

ENSG00000137275  (ver. 98.38)

Orthologs

Mouse Ripk1: ENSMUSG00000021408

UniProt

Q13546

neXtProt

NX_Q13546

Human splice variants
Mouse splice variants