MPP1

This gene encodes the prototype of the membrane-associated guanylate kinase (MAGUK) family proteins. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. The encoded protein is an extensively palmitoylated membrane phosphoprotein containing a PDZ domain, a Src homology 3 (SH3) motif, and a guanylate kinase domain. This gene product interacts with various cytoskeletal proteins and cell junctional proteins in different tissue and cell types, and may be involved in the regulation of cell shape, hair cell development, neural patterning of the retina, and apico-basal polarity and tumor suppression pathways in non-erythroid cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

Description

Membrane palmitoylated protein 1

Tissue specificity

Tissue enhanced (bone marrow)

Subcell location

Plasma membrane, Centriolar satellite

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

X (154778684 - 154821007)

Ensembl ID

ENSG00000130830  (ver. 103.38)

Orthologs

Mouse Mpp1: ENSMUSG00000031402

UniProt

Q00013

neXtProt

NX_Q00013

Human splice variants
Mouse splice variants

Protein structure