DAG1

gene product
156DAG, A3a, AGRNR, DAG
Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants all encoding the same protein. [provided by RefSeq, Apr 2010]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

  or   Clear
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Validated within AVI
Eligible for validation within AVI
338 antibodies from 37 providers.

Antibody properties

General

Applications

or Cancel
AntibodyRefsTypeWBELICCIPIHCFC
GeneTex
6 antibodies
Novus Biologicals
8 antibodies
antibodies-online
107 antibodies
NovoPro Bioscience Inc.
5 antibodies
R&D Systems
1 antibody
Invitrogen Antibodies
5 antibodies
Proteintech Group
1 antibody
Affinity Biosciences
2 antibodies
Abnova Corporation
3 antibodies
LifeSpan BioSciences, Inc.
43 antibodies
Aviva Systems Biology
5 antibodies
BioLegend
6 antibodies
Badrilla Ltd
1 antibody
Abgent
5 antibodies
ProSci
2 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Antibodies.com
1 antibody
Boster Biological Technology
1 antibody
Acris Antibodies GmbH
3 antibodies
Biorbyt
17 antibodies
Everest Biotech
1 antibody
NSJ Bioreagents
1 antibody
Creative Biolabs
28 antibodies
OriGene
4 antibodies
EMD Millipore
2 antibodies
Arigo
1 antibody
Santa Cruz Biotechnology
1 antibody
MyBioSource
6 antibodies
St John's Laboratory
3 antibodies
Creative Diagnostics
9 antibodies
RayBiotech, Inc.
2 antibodies
RabMAbs
2 antibodies
United States Biological
27 antibodies
GenWay
1 antibody
Sigma-Aldrich
2 antibodies
Abbexa
1 antibody