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BMI1
BMI1 proto-oncogene, polycomb ring fingerPCGF4, RNF51
This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene. [provided by RefSeq, Sep 2015]
Top validated antibodies |
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| Proteintech Group |  10832-1-AP |
35 references | Polyclonal |
WB
EL
ICC
IP
IHC
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| antibodies-online | ABIN968985 |
2 references | Monoclonal |
WB
EL
ICC
IHC
FC
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| LSBio | LS-C169434 |
Monoclonal |
WB
EL
ICC
IHC
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| GeneTex | GTX114008 |
9 references | Polyclonal |
WB
ICC
IP
IHC
|
|
| Novus Biologicals | NBP1-96140 |
2 references | Monoclonal |
WB
ICC
IP
FC
ChIP
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