MED12

gene product
ARC240, CAGH45, FGS1, HOPA, KIAA0192, Kto, OKS, OPA1, TNRC11, TRAP230
The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq, Aug 2009]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

Antibody

  or   Clear
Enhanced validation
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Validated within AVI
Eligible for validation within AVI
208 antibodies from 28 providers.

Antibody properties

General

Applications

or Cancel
Antibody
Novus Biologicals
25 antibodies
antibodies-online
88 antibodies
Proteintech Group
1 antibody
Atlas Antibodies
2 antibodies
Invitrogen Antibodies
7 antibodies
Bethyl Laboratories
2 antibodies
Abnova Corporation
3 antibodies
LifeSpan BioSciences, Inc.
22 antibodies
Cell Signaling Technology, Inc
2 antibodies
GeneTex
1 antibody
NovoPro Bioscience Inc.
1 antibody
Biorbyt
21 antibodies
Aviva Systems Biology
1 antibody
OriGene
3 antibodies
Creative Biolabs
4 antibodies
Arigo
2 antibodies
Bioworld Technology, Inc
1 antibody
St John's Laboratory
2 antibodies
Affinity Biosciences
1 antibody
MyBioSource
6 antibodies
Sigma-Aldrich
2 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Creative Diagnostics
1 antibody
Abbexa
3 antibodies
Bioss
3 antibodies
Everest Biotech
1 antibody
ProSci
1 antibody
Abgent
1 antibody