FBXO43

Members of the F-box protein family, such as FBXO43, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]). [supplied by OMIM, Mar 2008]

Description

F-box protein 43

Protein family

Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Predicted intracellular proteins, Protein evidence (Peptideatlas)

Chromosome

8:q22.2 (100133351 - 100145817)

Ensembl ID

ENSG00000156509  (ver. 98.38)

Orthologs

Mouse Fbxo43: ENSMUSG00000048230

UniProt

Q4G163

neXtProt

NX_Q4G163

Human splice variants
Mouse splice variants