MRC1

The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment. [provided by RefSeq, Sep 2015]

Description

mannose receptor C-type 1

Protein family

CD markers, FDA approved drug targets, Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Plasma proteins, Predicted membrane proteins, Protein evidence (Peptideatlas)

Chromosome

10:p12.33 (17809348 - 17911164)

Ensembl ID

ENSG00000260314  (ver. 99.38)

Orthologs

Mouse Mrc1: ENSMUSG00000026712

UniProt

P22897

neXtProt

NX_P22897

Human splice variants
Mouse splice variants