PROC

This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis. [provided by RefSeq, Dec 2009]

Description

Protein C, inactivator of coagulation factors Va and VIIIa

Tissue specificity

Tissue enriched (liver)

Predicted location

Intracellular, Secreted to blood

Protein family

Cancer-related genes
Candidate cardiovascular disease genes
Disease related genes
Enzymes
FDA approved drug targets
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

2 (127418427 - 127429242)

Ensembl ID

ENSG00000115718  (ver. 103.38)

Orthologs

-

UniProt

P04070

neXtProt

NX_P04070

Human splice variants

Protein structure