HSPG2

gene product
perlecan, PRCAN, SJS1
This gene encodes the perlecan protein, which consists of a core protein to which three long chains of glycosaminoglycans (heparan sulfate or chondroitin sulfate) are attached. The perlecan protein is a large multidomain proteoglycan that binds to and cross-links many extracellular matrix components and cell-surface molecules. It has been shown that this protein interacts with laminin, prolargin, collagen type IV, FGFBP1, FBLN2, FGF7 and transthyretin, etc., and it plays essential roles in multiple biological activities. Perlecan is a key component of the vascular extracellular matrix, where it helps to maintain the endothelial barrier function. It is a potent inhibitor of smooth muscle cell proliferation and is thus thought to help maintain vascular homeostasis. It can also promote growth factor (e.g., FGF2) activity and thus stimulate endothelial growth and re-generation. It is a major component of basement membranes, where it is involved in the stabilization of other molecules as well as being involved with glomerular permeability to macromolecules and cell adhesion. Mutations in this gene cause Schwartz-Jampel syndrome type 1, Silverman-Handmaker type of dyssegmental dysplasia, and tardive dyskinesia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]
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Invitrogen Antibodies
8 antibodies
NSJ Bioreagents
3 antibodies
Novus Biologicals
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antibodies-online
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NovoPro Bioscience Inc.
2 antibodies
R&D Systems
3 antibodies
LifeSpan BioSciences, Inc.
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Proteintech Group
1 antibody
OriGene
2 antibodies
Santa Cruz Biotechnology
1 antibody
Acris Antibodies GmbH
2 antibodies
Biorbyt
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Boster Biological Technology
2 antibodies
GeneTex
1 antibody
MyBioSource
8 antibodies
Creative Biolabs
3 antibodies
United States Biological
12 antibodies
Abbiotec
3 antibodies
EMD Millipore
4 antibodies
Enzo Life Sciences
1 antibody
Creative Diagnostics
3 antibodies
GenWay
2 antibodies
Arigo
1 antibody
Sigma-Aldrich
1 antibody
Abnova Corporation
6 antibodies