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Protein structure
CD38
CD38 moleculeThe protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Top validated antibodies |
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| Proteintech Group |  25284-1-AP |
6 references | Polyclonal |
WB
EL
IHC
FC
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| LSBio | LS-C331640 |
Polyclonal |
WB
IHC
BN
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| NSJ Bioreagents | F48288 |
Polyclonal |
WB
EL
ICC
IHC
FC
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| Invitrogen Antibodies | MA5-14413 |
10 references | Monoclonal |
WB
IHC
FC
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| Novus Biologicals | NBP1-47462 |
1 references | Monoclonal |
WB
EL
ICC
IHC
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