IGF2BP3

The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq, Jul 2008]

Description

Insulin like growth factor 2 mRNA binding protein 3

Tissue specificity

Tissue enhanced (lymphoid tissue, placenta)

Subcell location

Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

7 (23310209 - 23470491)

Ensembl ID

ENSG00000136231  (ver. 103.38)

Orthologs

Mouse Igf2bp3: ENSMUSG00000029814

UniProt

O00425

neXtProt

NX_O00425

Human splice variants
Mouse splice variants

Protein structure