PDGFRA

This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012]

Description

Platelet derived growth factor receptor alpha

Tissue specificity

Tissue enhanced (ovary)

Subcell location

Nucleoplasm, Plasma membrane, Cell Junctions

Predicted location

Intracellular, Membrane

Protein family

Cancer-related genes
CD markers
Disease related genes
Enzymes
FDA approved drug targets
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
RAS pathway related proteins

Chromosome

4 (54229280 - 54298245)

Ensembl ID

ENSG00000134853  (ver. 103.38)

Orthologs

Mouse Pdgfra: ENSMUSG00000029231

UniProt

P16234

neXtProt

NX_P16234

Human splice variants
Mouse splice variants

Protein structure