Tissue expression
Cell line expression
Protein structure
TNFRSF21
TNF receptor superfamily member 21CD358, DR6
This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. [provided by RefSeq, Jul 2013]
Top validated antibodies |
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LSBio | LS-C376901 | Polyclonal |
WB
EL
IHC
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Abnova Corporation | MAB3877 | 3 references | Monoclonal |
ICC
FC |
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Enzo Life Sciences | ALX-210-569-C100 | 2 references | Polyclonal |
WB
ICC |
|
Biorbyt | orb101582 | Polyclonal |
WB
EL
ICC
IHC |
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Invitrogen Antibodies | PA5-105426 | Polyclonal |
WB
ICC
IHC
|
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Supportive data in Antibodypedia
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