TNFRSF21

This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. [provided by RefSeq, Jul 2013]

Description

TNF receptor superfamily member 21

Tissue specificity

Tissue enhanced (brain, urinary bladder)

Subcell location

Plasma membrane, Cytosol

Predicted location

Membrane

Protein family

CD markers
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Plasma proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

6 (47231532 - 47309905)

Ensembl ID

ENSG00000146072  (ver. 103.38)

Orthologs

Mouse Tnfrsf21: ENSMUSG00000023915

UniProt

O75509

neXtProt

NX_O75509

Human splice variants
Mouse splice variants

Protein structure