ITGA6

gene product
CD49f
The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
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Bethyl Laboratories
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Proteintech Group
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MyBioSource
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STEMCELL Technologies Inc
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GenWay
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Cell Signaling Technology, Inc
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Signalway Antibody LLC
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Sigma-Aldrich
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Abbexa
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RayBiotech, Inc.
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