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Protein structure
ITGA6
Integrin subunit alpha 6CD49f
The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Top validated antibodies |
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| antibodies-online |  ABIN2838034 |
6 references | Monoclonal |
WB
ICC
IHC
FC
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| GeneTex | GTX76413 |
5 references | Monoclonal |
IP
IHC
FC
BN
FA
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| Invitrogen Antibodies | 14-0495-82 |
52 references | Monoclonal |
IP
IHC
FC
OA
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| Novus Biologicals | NBP1-85747 |
5 references | Polyclonal |
WB
IP
IHC
|
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| Proteintech Group | 27189-1-AP |
20 references | Polyclonal |
WB
EL
IHC
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