PDK2

This gene encodes a member of the pyruvate dehydrogenase kinase family. The encoded protein phosphorylates pyruvate dehydrogenase, down-regulating the activity of the mitochondrial pyruvate dehydrogenase complex. Overexpression of this gene may play a role in both cancer and diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

Description

pyruvate dehydrogenase kinase 2

Protein family

Enzymes, Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Predicted intracellular proteins, Protein evidence (Peptideatlas)

Chromosome

17:q21.33 (50094737 - 50112152)

Ensembl ID

ENSG00000005882  (ver. 99.38)

Orthologs

Mouse Pdk2: ENSMUSG00000038967

UniProt

Q15119

neXtProt

NX_Q15119

Human splice variants
Mouse splice variants