ANGPTL4

This gene encodes a glycosylated, secreted protein containing a C-terminal fibrinogen domain. The encoded protein is induced by peroxisome proliferation activators and functions as a serum hormone that regulates glucose homeostasis, lipid metabolism, and insulin sensitivity. This protein can also act as an apoptosis survival factor for vascular endothelial cells and can prevent metastasis by inhibiting vascular growth and tumor cell invasion. The C-terminal domain may be proteolytically-cleaved from the full-length secreted protein. Decreased expression of this gene has been associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4. [provided by RefSeq, Sep 2013]

Description

Angiopoietin like 4

Tissue specificity

Tissue enhanced (adipose tissue, breast, liver)

Subcell location

Nucleoplasm, Vesicles

Predicted location

Intracellular, Secreted to blood

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

19 (8363289 - 8374370)

Ensembl ID

ENSG00000167772  (ver. 103.38)

Orthologs

Mouse Angptl4: ENSMUSG00000002289

UniProt

Q9BY76

neXtProt

NX_Q9BY76

Human splice variants
Mouse splice variants

Protein structure