IRF5

This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Alternative promoter use and alternative splicing result in multiple transcript variants, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. [provided by RefSeq, Dec 2016]

Description

interferon regulatory factor 5

Protein family

Disease related genes, Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Predicted intracellular proteins, Protein evidence (Peptideatlas), Transcription factors

Chromosome

7:q32.1 (128937457 - 128950038)

Ensembl ID

ENSG00000128604  (ver. 99.38)

Orthologs

Mouse Irf5: ENSMUSG00000029771

UniProt

Q13568

neXtProt

NX_Q13568

Human splice variants
Mouse splice variants