PPIB

The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009]

Description

peptidylprolyl isomerase B (cyclophilin B)

Protein family

Disease related genes, Enzymes, Mapped to UniProt SWISS-PROT, Plasma proteins, Potential drug targets, Predicted secreted proteins, Protein evidence (Ezkurdia et al 2014), Protein evidence (Kim et al 2014)

Chromosome

15:q22.31 (64155812 - 64163205)

Ensembl ID

ENSG00000166794  (ver. 84.38)

Orthologs

Mouse Ppib: ENSMUSG00000032383

UniProt

P23284

neXtProt

NX_P23284

Human splice variants
Mouse splice variants