RASGRP2

The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Four alternatively spliced transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

Description

RAS guanyl releasing protein 2

Tissue specificity

Tissue enhanced (bone marrow, lymphoid tissue)

Subcell location

Plasma membrane

Predicted location

Intracellular

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
RAS pathway related proteins

Chromosome

11 (64726911 - 64745456)

Ensembl ID

ENSG00000068831  (ver. 103.38)

Orthologs

Mouse Rasgrp2: ENSMUSG00000032946

UniProt

Q7LDG7

neXtProt

NX_Q7LDG7

Human splice variants
Mouse splice variants

Protein structure