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Protein structure
HDAC3
Histone deacetylase 3HD3, KDAC3, RPD3, RPD3-2
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| GeneTex |  GTX109679 |
4 references | Polyclonal |
WB
ICC
IP
IHC
ChIP
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| Invitrogen Antibodies | PA5-29026 |
1 references | Polyclonal |
WB
ICC
IP
IHC
ChIP
OA
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| Proteintech Group | 10255-1-AP |
48 references | Polyclonal |
WB
EL
IP
IHC
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| Novus Biologicals | NB100-1669 |
7 references | Polyclonal |
WB
ICC
IP
IHC
ChIP
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| NSJ Bioreagents | V9744 |
Monoclonal |
WB
EL
ICC
FC
PA
OA
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