Tissue expression
Cell line expression
Protein structure
ACLY
ATP citrate lyaseACL, ATPCL, CLATP
ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014]
Top validated antibodies |
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antibodies-online | ABIN1098143 | 2 references | Monoclonal |
WB
EL
ICC
IHC
FC
|
|
Invitrogen Antibodies | 15421-1-AP | Polyclonal |
WB
ICC
IP
IHC
FC
OA |
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GeneTex | GTX60666 | Monoclonal |
WB
EL
ICC
IHC
FC
|
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Novus Biologicals | NBP2-37429 | Monoclonal |
WB
EL
ICC
IHC
FC
|
||
LSBio | LS-C169149 | Monoclonal |
WB
EL
ICC
IHC |
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