FBL

This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin. [provided by RefSeq, Jul 2008]

Description

Fibrillarin

Tissue specificity

Low tissue specificity

Subcell location

Nucleoli fibrillar center

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

19 (39834458 - 39846379)

Ensembl ID

ENSG00000105202  (ver. 103.38)

Orthologs

Mouse Fbl: ENSMUSG00000046865

UniProt

P22087

neXtProt

NX_P22087

Human splice variants
Mouse splice variants

Protein structure