WEE1

This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase. [provided by RefSeq, Jul 2008]

Description

WEE1 G2 checkpoint kinase

Protein family

Cancer-related genes, Enzymes, Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Plasma proteins, Predicted intracellular proteins, Protein evidence (Peptideatlas)

Chromosome

11:p15.4 (9573670 - 9593457)

Ensembl ID

ENSG00000166483  (ver. 98.38)

Orthologs

Mouse Wee1: ENSMUSG00000031016

UniProt

P30291

neXtProt

NX_P30291

Human splice variants
Mouse splice variants