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Protein structure
HUWE1
HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1Ib772, KIAA0312, UREB1
This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related)). This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with Turner type X-linked syndromic cognitive disability. [provided by RefSeq, Aug 2013]
Top validated antibodies |
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| Novus Biologicals |  NB100-652 |
17 references | Polyclonal |
WB
ICC
IP
IHC
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| antibodies-online | ABIN152075 |
14 references | Polyclonal |
WB
ICC
IP
IHC
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| Proteintech Group | 19430-1-AP |
10 references | Polyclonal |
WB
EL
IHC
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| Biorbyt | orb1519672 |
Recombinant |
WB
ICC
IP
IHC
FC
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| LSBio | LS-C287372 |
Polyclonal |
WB
IP
IHC
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