BRCA1

gene product
BRCC1, FANCS, PPP1R53, RNF53
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009]
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GeneTex
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Invitrogen Antibodies
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Proteintech Group
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antibodies-online
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R&D Systems
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Biorbyt
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LifeSpan BioSciences, Inc.
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NovoPro Bioscience Inc.
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Cell Signaling Technology, Inc
3 antibodies
Affinity Biosciences
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Acris Antibodies GmbH
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4 antibodies
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Atlas Antibodies
2 antibodies
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11 antibodies
Boster Biological Technology
4 antibodies
Abbkine Scientific Co.Ltd.
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132 antibodies
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Leading Biology
6 antibodies
EMD Millipore
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RayBiotech, Inc.
4 antibodies
Sigma-Aldrich
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CPTAC
4 antibodies