Tissue expression
Cell line expression
Protein structure

BRCA1

BRCA1 DNA repair associated
BRCC1, FANCS, PPP1R53, RNF53 
This gene encodes a 190 kD nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The BRCA1 gene contains 22 exons spanning about 110 kb of DNA. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2020]
More gene data

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2576 antibodies from 45 providers.

Antibody properties

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AntibodyRefsTypeWBELICCIPIHCFC
GeneTex
22 antibodies
Novus Biologicals
200 antibodies
Invitrogen Antibodies
99 antibodies
antibodies-online
906 antibodies
Proteintech Group
3 antibodies
R&D Systems
4 antibodies
Biorbyt
366 antibodies
OriGene
108 antibodies
Cusabio Biotech Co., Ltd
20 antibodies
NovoPro Bioscience Inc.
4 antibodies
Aviva Systems Biology
16 antibodies
Wuhan Fine Biotech Co., Ltd.
2 antibodies
Signalway Antibody LLC
5 antibodies
St John's Laboratory
15 antibodies
Bioworld Technology, Inc
5 antibodies
Cell Signaling Technology, Inc
3 antibodies
Affinity Biosciences
8 antibodies
Abnova Corporation
27 antibodies
Acris Antibodies GmbH
29 antibodies
Bethyl Laboratories
11 antibodies
QED Bioscience
2 antibodies
Arigo
6 antibodies
Atlas Antibodies
2 antibodies
NSJ Bioreagents
7 antibodies
Boster Biological Technology
6 antibodies
ProSci
11 antibodies
Abbkine Scientific Co.Ltd.
7 antibodies
Abgent
6 antibodies
MyBioSource
10 antibodies
BioLegend
2 antibodies
HUABIO Research
1 antibody
GenWay
19 antibodies
United States Biological
132 antibodies
Creative Biolabs
34 antibodies
Creative Diagnostics
22 antibodies
Abbexa
37 antibodies
Abbiotec
2 antibodies
SignalChem
1 antibody
MilliporeSigma / Merck KGaA
11 antibodies
Leading Biology
6 antibodies
EMD Millipore
6 antibodies
RayBiotech, Inc.
4 antibodies
CPTAC
4 antibodies