Tissue expression
Cell line expression
Protein structure
TTR
TransthyretinCTS, CTS1, HsT2651, PALB
This gene encodes one of the three prealbumins, which include alpha-1-antitrypsin, transthyretin and orosomucoid. The encoded protein, transthyretin, is a homo-tetrameric carrier protein, which transports thyroid hormones in the plasma and cerebrospinal fluid. It is also involved in the transport of retinol (vitamin A) in the plasma by associating with retinol-binding protein. The protein may also be involved in other intracellular processes including proteolysis, nerve regeneration, autophagy and glucose homeostasis. Mutations in this gene are associated with amyloid deposition, predominantly affecting peripheral nerves or the heart, while a small percentage of the gene mutations are non-amyloidogenic. The mutations are implicated in the etiology of several diseases, including amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis and carpal tunnel syndrome. [provided by RefSeq, Aug 2017]
Top validated antibodies |
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Invitrogen Antibodies | MA5-32634 | 1 references | Monoclonal |
WB
ICC
IHC
FC
OA
|
|
Novus Biologicals | NBP2-52575 | 1 references | Monoclonal |
WB
EL
ICC
IHC
FC
|
|
antibodies-online | ABIN5875576 | Monoclonal |
WB
EL
ICC
IHC
FC
|
||
Atlas Antibodies | HPA002550 | 3 references | Polyclonal |
WB
ICC
IHC
|
|
Proteintech Group | 11891-1-AP | 24 references | Polyclonal |
WB
EL
IHC
|
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Supportive data in Antibodypedia
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Recommended by provider