PTPN6

gene product
HCP, HCPH, PTP-1C, SHP-1, SHP1
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

Antibody

  or   Clear
Enhanced validation
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Validated within AVI
Eligible for validation within AVI
972 antibodies from 45 providers.

Antibody properties

General

Applications

or Cancel
Antibody
Proteintech Group
1 antibody
Novus Biologicals
12 antibodies
Invitrogen Antibodies
25 antibodies
GeneTex
16 antibodies
antibodies-online
343 antibodies
Atlas Antibodies
1 antibody
Biorbyt
61 antibodies
OriGene
26 antibodies
Abnova Corporation
21 antibodies
Santa Cruz Biotechnology
1 antibody
LifeSpan BioSciences, Inc.
97 antibodies
Affinity Biosciences
6 antibodies
NovoPro Bioscience Inc.
12 antibodies
Acris Antibodies GmbH
25 antibodies
Signalway Antibody LLC
2 antibodies
Abgent
9 antibodies
Bioworld Technology, Inc
3 antibodies
Aviva Systems Biology
8 antibodies
BioLegend
2 antibodies
R&D Systems
2 antibodies
ProSci
7 antibodies
Boster Biological Technology
2 antibodies
Arigo
7 antibodies
Cell Signaling Technology, Inc
2 antibodies
St John's Laboratory
11 antibodies
RabMAbs
5 antibodies
Antibodies.com
2 antibodies
Bethyl Laboratories
1 antibody
Creative Biolabs
43 antibodies
Abbkine Scientific Co.Ltd.
4 antibodies
Everest Biotech
2 antibodies
NSJ Bioreagents
2 antibodies
MyBioSource
11 antibodies
Leading Biology
9 antibodies
Abbiotec
1 antibody
United States Biological
94 antibodies
GenWay
6 antibodies
RayBiotech, Inc.
3 antibodies
Creative Diagnostics
4 antibodies
Abiocode, Inc.
1 antibody
EMD Millipore
4 antibodies
Abbexa
3 antibodies
Sigma-Aldrich
4 antibodies
Exalpha Biologicals, Inc.
1 antibody