FUBP1

gene product
FBP, FUBP
The protein encoded by this gene is a single stranded DNA-binding protein that binds to multiple DNA elements, including the far upstream element (FUSE) located upstream of c-myc. Binding to FUSE occurs on the non-coding strand, and is important to the regulation of c-myc in undifferentiated cells. This protein contains three domains, an amphipathic helix N-terminal domain, a DNA-binding central domain, and a C-terminal transactivation domain that contains three tyrosine-rich motifs. The N-terminal domain is thought to repress the activity of the C-terminal domain. This protein is also thought to bind RNA, and contains 3'-5' helicase activity with in vitro activity on both DNA-DNA and RNA-RNA duplexes. Aberrant expression of this gene has been found in malignant tissues, and this gene is important to neural system and lung development. Binding of this protein to viral RNA is thought to play a role in several viral diseases, including hepatitis C and hand, foot and mouth disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

  or   Clear
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Validated within AVI
Eligible for validation within AVI
266 antibodies from 31 providers.

Antibody properties

General

Applications

or Cancel
AntibodyRefsTypeWBELICCIPIHCFC
GeneTex
2 antibodies
Invitrogen Antibodies
3 antibodies
Atlas Antibodies
1 antibody
Novus Biologicals
9 antibodies
antibodies-online
91 antibodies
Abnova Corporation
6 antibodies
LifeSpan BioSciences, Inc.
37 antibodies
Proteintech Group
1 antibody
Abgent
4 antibodies
Affinity Biosciences
1 antibody
Boster Biological Technology
1 antibody
NovoPro Bioscience Inc.
1 antibody
Antibodies.com
1 antibody
NSJ Bioreagents
1 antibody
OriGene
5 antibodies
Aviva Systems Biology
4 antibodies
Biorbyt
5 antibodies
St John's Laboratory
3 antibodies
ProSci
5 antibodies
MyBioSource
6 antibodies
Everest Biotech
1 antibody
Creative Diagnostics
6 antibodies
FabGennix
3 antibodies
Creative Biolabs
2 antibodies
United States Biological
45 antibodies
Abiocode, Inc.
1 antibody
Sigma-Aldrich
5 antibodies
RayBiotech, Inc.
1 antibody
GenWay
1 antibody
Acris Antibodies GmbH
2 antibodies