S100A7

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. The protein is overexpressed in hyperproliferative skin diseases, exhibits antimicrobial activities against bacteria and induces immunomodulatory activities. [provided by RefSeq, Nov 2014]

Description

S100 calcium binding protein A7

Tissue specificity

Group enriched (esophagus, lymphoid tissue, skin , vagina)

Subcell location

Cytosol

Predicted location

Intracellular, Secreted in other tissues

Protein family

Cancer-related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (153457744 - 153460651)

Ensembl ID

ENSG00000143556  (ver. 103.38)

Orthologs

-

UniProt

P31151

neXtProt

NX_P31151

Human splice variants

Protein structure