Tissue expression
Cell line expression
Protein structure

CCNE1

Cyclin E1
CCNE 
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. [provided by RefSeq, Apr 2016]
More gene data

All Antibodies

 

Filters

Application

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

Antigen sequence

Epitope

Antibody

  or   Clear
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
1178 antibodies from 48 providers.

Antibody properties

Applications

or Cancel
AntibodyRefsTypeWBELICCIPIHCFC
Invitrogen Antibodies
63 antibodies
antibodies-online
401 antibodies
Proteintech Group
2 antibodies
Abnova Corporation
19 antibodies
OriGene
34 antibodies
NSJ Bioreagents
3 antibodies
Aviva Systems Biology
9 antibodies
Acris Antibodies GmbH
28 antibodies
Boster Biological Technology
8 antibodies
Cusabio Biotech Co., Ltd
17 antibodies
Affinity Biosciences
7 antibodies
GeneTex
12 antibodies
Novus Biologicals
13 antibodies
Cell Signaling Technology, Inc
3 antibodies
Abgent
9 antibodies
Atlas Antibodies
1 antibody
St John's Laboratory
10 antibodies
Bioworld Technology, Inc
4 antibodies
HUABIO Research
2 antibodies
NovoPro Bioscience Inc.
3 antibodies
Bethyl Laboratories
2 antibodies
R&D Systems
3 antibodies
Enzo Life Sciences
2 antibodies
ProSci
7 antibodies
Abbkine Scientific Co.Ltd.
5 antibodies
RabMAbs
7 antibodies
Exalpha Biologicals, Inc.
1 antibody
FineTest Biotech
1 antibody
Arigo
5 antibodies
Abbexa
21 antibodies
RayBiotech, Inc.
5 antibodies
MilliporeSigma / Merck KGaA
8 antibodies
Creative Biolabs
44 antibodies
Sino Biological Inc.
4 antibodies
Signalway Antibody LLC
1 antibody
United States Biological
117 antibodies
Spring Bioscience
8 antibodies
Leading Biology
8 antibodies
MyBioSource
16 antibodies
Creative Diagnostics
9 antibodies
EMD Millipore
4 antibodies
GenWay
6 antibodies
Aladdin Scientific Corporation
1 antibody
QED Bioscience
1 antibody
eBioscience, An Affymetrix Company
2 antibodies
Rockland Immunochemicals, Inc.
1 antibody