CCNE1

gene product
CCNE
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available. [provided by RefSeq, Jul 2008]
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1080 antibodies from 41 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Invitrogen Antibodies
18 antibodies
antibodies-online
401 antibodies
Abnova Corporation
19 antibodies
Biorbyt
60 antibodies
Aviva Systems Biology
9 antibodies
GeneTex
12 antibodies
Acris Antibodies GmbH
28 antibodies
OriGene
28 antibodies
Affinity Biosciences
7 antibodies
Novus Biologicals
30 antibodies
Boster Biological Technology
4 antibodies
Cell Signaling Technology, Inc
3 antibodies
Abgent
9 antibodies
Atlas Antibodies
1 antibody
LifeSpan BioSciences, Inc.
184 antibodies