MTAP

This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown. [provided by RefSeq, Jul 2008]

Description

methylthioadenosine phosphorylase

Protein family

Disease related genes, Enzymes, Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Protein evidence (Peptideatlas)

Chromosome

9:p21.3 (21802636 - 21937651)

Ensembl ID

ENSG00000099810  (ver. 99.38)

Orthologs

Mouse Mtap: ENSMUSG00000062937

UniProt

Q13126

neXtProt

NX_Q13126

Human splice variants
Mouse splice variants