TRAF6

gene product
RNF85
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain. Two alternatively spliced transcript variants, encoding an identical protein, have been reported. [provided by RefSeq, Feb 2012]
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503 antibodies from 41 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
GeneTex
5 antibodies
Novus Biologicals
19 antibodies
Invitrogen Antibodies
6 antibodies
Proteintech Group
1 antibody
Santa Cruz Biotechnology
1 antibody
antibodies-online
168 antibodies
Biorbyt
25 antibodies
Boster Biological Technology
4 antibodies
Bioworld Technology, Inc
2 antibodies
Abnova Corporation
10 antibodies
OriGene
15 antibodies
NovoPro Bioscience Inc.
8 antibodies
Acris Antibodies GmbH
15 antibodies
LifeSpan BioSciences, Inc.
77 antibodies
Atlas Antibodies
2 antibodies
Affinity Biosciences
2 antibodies
Arigo
1 antibody
Enzo Life Sciences
1 antibody
RabMAbs
5 antibodies
Abgent
10 antibodies
ProSci
2 antibodies
St John's Laboratory
2 antibodies
Bethyl Laboratories
1 antibody
Cell Signaling Technology, Inc
1 antibody
Abbkine Scientific Co.Ltd.
1 antibody
United States Biological
55 antibodies
R&D Systems
10 antibodies
Aviva Systems Biology
5 antibodies
BioLegend
2 antibodies
Creative Biolabs
6 antibodies
Abbiotec
1 antibody
NSJ Bioreagents
1 antibody
Rockland Immunochemicals, Inc.
1 antibody
Creative Diagnostics
6 antibodies
RayBiotech, Inc.
4 antibodies
Abbexa
3 antibodies
EMD Millipore
3 antibodies
FabGennix
3 antibodies
Sigma-Aldrich
4 antibodies
GenWay
3 antibodies