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GCLC
Glutamate-cysteine ligase catalytic subunitGCS, GLCL, GLCLC
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction. [provided by RefSeq, Oct 2010]
Top validated antibodies |
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| Proteintech Group |  12601-1-AP |
113 references | Polyclonal |
WB
EL
IP
IHC
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| antibodies-online | ABIN952477 |
3 references | Polyclonal |
WB
ICC
IHC
FC
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| Novus Biologicals | H00002729-M01 |
13 references | Monoclonal |
WB
EL
ICC
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| LSBio | LS-C166412 |
Polyclonal |
WB
ICC
IHC
|
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| Abnova Corporation | H00002729-M01 |
6 references | Monoclonal |
WB
EL
ICC
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